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How long does naltrexone stay in your system?

How long does naltrexone stay in your system?

Table of Contents

Naltrexone, a medication used in treating alcohol and opioid addiction, has varying durations in the body depending on its form of administration and individual factors. Let’s explore how long this medication remains effective and detectable in your system.

Understanding Naltrexone’s Duration

The duration of naltrexone in your system primarily depends on whether you take it orally or receive it as an injection. Oral naltrexone typically remains effective for 24 to 72 hours, while injectable naltrexone (Vivitrol) maintains its effectiveness for approximately one month.
Half-Life and Metabolism

The half-life of naltrexone varies by administration method:

  • Oral naltrexone: 4-5 hours
  • Injectable naltrexone: 5-10 days
  • Metabolite (6β-Naltrexol): 13 hours

    Detection Windows in Different Body Systems

    Blood Detection

    Naltrexone remains detectable in blood for approximately 24 hours after oral consumption.

Other Detection Methods

  • Urine: 4-6 hours
  • Saliva: Up to 24 hours
  • Hair: Up to 90 days

    Factors Affecting Duration

    Several personal factors influence how long naltrexone remains in your system:

  • Age
  • Weight
  • Metabolism rate
  • Overall health
  • Liver function
  • Medication dosage
  • Usage frequency

    Administration Methods and Effects

    Oral Naltrexone
    The medication begins working within an hour of consumption and typically stays active in the system for about eight hours.
    Injectable Naltrexone (Vivitrol)

    After intramuscular injection, the medication releases in phases:

  1. Initial release occurs within the first 24 hours
  2. Injection site hydration happens within 48 hours
  3. Sustained release continues over 30 days through polymer microsphere erosion

Peak Effectiveness

The medication reaches peak effectiveness at different times depending on the administration method:

  • Oral form: Within 1 hour of consumption
  • Injectable form: First peak at 2 hours post-injection, second peak between 48-72 hours

    Long-Term Considerations

    For injectable naltrexone users, effectiveness gradually decreases about two weeks after injection. Regular dosing every four weeks is necessary to maintain therapeutic levels.

    Clinical Applications

    The medication’s duration makes it particularly effective for:

  • Managing opioid addiction
  • Treating alcohol use disorder
  • Preventing relapse
  • Supporting long-term recovery goals


    Remember, while this information provides general guidelines, individual experiences may vary. Always follow your healthcare provider’s specific instructions regarding naltrexone use and timing.

At Asana Recovery, we understand that medication-assisted treatment like naltrexone plays a vital role in overcoming alcohol and opioid addiction. Our dedicated team of professionals provides personalized care to help you navigate your recovery journey, ensuring you have the information and support needed to make the best choices for your health. Whether you’re starting naltrexone treatment or looking to manage its effects, we’re here to guide you every step of the way. Contact Asana Recovery today to learn how our programs can support your path to lasting recovery.

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