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How Much Are Ketamine Infusions for Depression?

How Much Are Ketamine Infusions for Depression?

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Ketamine therapy has emerged as a groundbreaking treatment for depression, especially for those who have not responded well to traditional antidepressants. However, the question on many potential patients’ minds is, “How much are ketamine infusions for depression?” Understanding the cost of ketamine therapy and the factors influencing pricing is essential for individuals considering this treatment.


A single ketamine infusion can range from $275 to $1,300 per session, depending on treatment type, clinic location, and provider expertise. A full treatment course often requires multiple sessions, which can push total costs to $2,000–$8,000+. While ketamine therapy prices vary significantly, options like insurance coverage, financial assistance, and payment plans can help manage expenses.


This guide provides a detailed breakdown of ketamine infusion therapy costs, compares pricing for different treatment types, and explores affordability options to help you make an informed decision about pursuing ketamine therapy.

Understanding Ketamine Therapy Costs

Factors That Influence the Cost of Ketamine Therapy

Several factors impact the cost of ketamine treatment, making prices highly variable across different clinics. Understanding these elements can help patients plan for expenses more effectively.

  • Treatment Type: The price differs significantly between IV infusions, intramuscular injections (IM), nasal spray (Spravato or generic ketamine nasal spray), and oral tablets. Each type has its own set of costs and benefits, with IV infusions typically being the most expensive due to the need for in-clinic administration and monitoring.
  • Clinic Location: Treatment in major cities like New York or Los Angeles tends to be more expensive than in smaller towns. This is often due to higher operational costs, including rent and staffing expenses.
  • Facility Type: Private ketamine clinics often charge more than hospitals due to specialized care and personalized attention. Private clinics may offer more amenities and a more comfortable environment, which can justify the higher cost.
  • Medical Supervision: More monitoring = higher costs. For example, IV ketamine and Spravato require in-clinic administration, which involves medical staff and equipment costs, while generic nasal spray and oral ketamine are more affordable at-home options that do not require professional supervision.
  • Insurance Coverage: Many insurance plans do not cover ketamine infusions, but Spravato may be partially covered. This lack of coverage is a significant factor in the overall cost, as patients often have to pay out-of-pocket for treatments.
  • Additional Costs: Patients may need to pay for consultations, psychotherapy, or follow-up appointments, adding to the overall ketamine therapy cost. These additional services can enhance the effectiveness of the treatment but also increase the financial burden.

Cost Breakdown by Ketamine Treatment Type

IV Ketamine Infusions – The Most Common Option

IV ketamine infusion therapy cost is the highest among treatment types due to the need for in-clinic administration and monitoring.

  • Cost per session: $400–$1,000+ per infusion.
  • Full treatment cost: $2,000–$6,000+ for a 4-6 session protocol.
  • Why it’s expensive: Requires professional medical monitoring, specialized equipment, and a controlled environment to ensure safety.
  • Insurance coverage: Typically not covered, but partial reimbursement may be available in some cases.

Intramuscular (IM) Ketamine Injections

  • Cost per session: $275–$400.
  • Full treatment cost: $1,600–$3,000 for 4-6 sessions.
  • Why it’s cheaper than IV infusions: Less medical supervision is needed, reducing the overall cost. However, IM injections still require some level of medical oversight.

Ketamine Nasal Spray (Spravato vs. Generic Ketamine Spray)

Spravato (esketamine) is FDA-approved for depression, while generic ketamine nasal spray is a compounded medication with lower costs but fewer regulations.

  • Spravato medication cost: $600–$900 per dose (without insurance).
  • Total Spravato treatment cost: $10,800–$15,600 for the full 8-week protocol.
  • Generic ketamine nasal spray cost: $100–$200 per 30 ml bottle.
  • Insurance coverage: Spravato may be covered with pre-authorization; generic nasal spray is rarely covered due to its compounded nature.

Oral Ketamine (Tablets, Lozenges, Troches)

  • Cost per prescription: $75–$200 per month.
  • Least expensive form of ketamine therapy.
  • At-home option but lacks FDA approval and standardization. Oral ketamine is often used off-label, which can affect its availability and cost.

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Why is Ketamine Therapy So Expensive?

Many people ask, “Why is ketamine treatment so expensive?” The cost of ketamine infusion therapy is high due to several factors:

  • Medical Supervision: IV and ketamine infusion costs include doctor and nursing staff fees, which are significant.
  • Lack of FDA Approval: Ketamine for depression is used off-label, meaning insurance rarely covers ketamine therapy price. This lack of coverage shifts the financial burden to patients.
  • Specialized Equipment & Facilities: Clinics must maintain safe environments, which includes purchasing and maintaining specialized equipment, adding to costs.
  • Extensive Research & Training: Providers undergo specialized training to administer ketamine safely, which is a costly process.

Insurance Coverage for Ketamine Therapy

Does Insurance Cover Ketamine Infusions?

Insurance coverage for ketamine therapy cost varies:

  • IV ketamine infusions: Rarely covered by insurance, as they are off-label for depression.
  • Spravato: FDA-approved, sometimes covered (patients may qualify for co-pay assistance programs).
  • Generic ketamine nasal spray & oral ketamine: Not covered.

How to Check If Your Insurance Covers Ketamine Therapy

Some insurers partially reimburse ketamine treatments, so always verify before starting. It’s crucial to confirm coverage to avoid unexpected expenses.

Affordable Ketamine Treatment: Options for Lowering Costs

Finding cheap ketamine treatment can be challenging, but options exist for reducing costs:

  • Payment Plans & Financing: Many ketamine clinics offer installment plans to help spread out the cost over time.
  • HSA/FSA Accounts: Some patients use pre-tax medical accounts to cover ketamine treatment, which can help reduce the financial burden.
  • Non-Profit Assistance: Some organizations help fund treatment for eligible patients, providing financial aid to those who need it.
  • Discounted Treatment Programs: Some clinics provide cheaper ketamine therapy based on income, offering more affordable options for those with financial constraints.

Conclusion: Is Ketamine Therapy Worth the Cost?

While ketamine treatment for depression cost can be high, many patients find it life-changing. Options like financial assistance, payment plans, and Spravato insurance coverage can help make ketamine therapy cost more manageable. If you’re considering ketamine-assisted psychotherapy cost or ketamine infusion therapy cost, consult a professional to determine the best path for your mental health needs.
Would you like help finding an affordable ketamine therapy clinic? Reach out today to explore your options and discuss how to make ketamine therapy more accessible.

Start Your Journey to Healing with Asana Recovery

At Asana Recovery, we understand that seeking treatment for depression can be overwhelming, especially when considering the cost of ketamine therapy. Our compassionate team is here to help you explore affordable ketamine infusion options, navigate insurance coverage, and find a treatment plan tailored to your needs. Don’t let cost be a barrier to getting the care you deserve. Contact Asana Recovery today to learn more about our ketamine-assisted treatment programs and take the first step toward a brighter future.

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FAQs About Ketamine Infusion Therapy Costs


How much does ketamine therapy cost near me?

The cost of ketamine therapy near me depends on location but typically starts at $275–$400 for IM injections and $400+ for IV infusions. Prices vary based on clinic reputation, city, and level of care provided.

How much is a ketamine infusion therapy session?

A single ketamine infusion therapy session can cost between $275 and $1,300, with most clinics charging $400–$1,000 per session.

What is the total cost of a full ketamine treatment protocol?

The total cost of ketamine infusion therapy varies, but most full protocols (4-6 sessions) cost between $2,000 and $8,000.

Is ketamine therapy covered by insurance?

Insurance rarely covers IV ketamine for depression. However, Spravato (esketamine nasal spray) is FDA-approved and may be covered with pre-authorization.

What is the cheapest form of ketamine therapy?

Oral ketamine tablets and generic ketamine nasal spray are typically the cheapest options, costing between $75 and $200 per month.

Why is ketamine so expensive?

Ketamine therapy is costly due to medical supervision, lack of FDA approval for depression, specialized clinic settings, and extensive provider training.

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