Adderall remains one of the most widely prescribed medications in the United States, particularly for attention deficit hyperactivity disorder (ADHD). One of its most recognizable forms is the E 404 orange pill. But despite its popularity, many people wonder: what exactly is this round orange pill with an “E 404” imprint, and how does it differ from other Adderall variants like the E 401 orange pill, A 80 orange pill, or E 344 pink pill? In this guide, we dive into the uses, dosage, appearance, effects, and risks associated with the e404 pill, along with identifying fake versions and understanding the addiction potential.

What Is the E 404 Orange Pill?

The E 404 orange round pill is a generic version of Adderall that contains a combination of amphetamine and dextroamphetamine. As a central nervous system (CNS) stimulant, it helps boost dopamine and norepinephrine activity in the brain. These effects improve concentration, attention span, and impulse control—making it highly effective for ADHD, narcolepsy, and sometimes even off-label cognitive enhancement.

Also known as Lifestar 404, this pill is an instant-release formula, designed to provide fast-acting relief from symptoms of inattention and fatigue. It belongs to a group of similar pills like the E 401, E 504, E 505 orange pill, and N34 orange pill.

What Does the E 404 Pill Look Like?

This round orange pill with E 404 stamped on one side is widely known among patients, pharmacists, and even law enforcement. Often mistaken for other orange pills such as A 08 orange pill, A 78, or E 04 pill, it’s important to verify pill markings accurately.

• Imprint: E 404
  
  
• Color: Orange
  
  
• Shape: Round
  
  

Also referred to as the 404 orange pill, orange circular pill, or pill e404, it stands apart from blue variants like E 344 pink pill and G454 orange capsule.

Is the E 404 Orange Pill the Same as Adderall?

Yes. The E404 orange pill is a generic Adderall formulation manufactured by Lifestar. It contains the same active ingredients as branded Adderall. Unlike the E 401 pill, E 504 pill, or E 344 pink circle pill, the E 404 pill is commonly used to deliver 30 mg of amphetamine salts in an instant-release format.

People often ask whether E 404 orange pill is real or fake, or search for Adderall round orange pill and orange Adderall capsule—all of which refer to this generic version.

E 404 Orange Pill Dosage and Strength

The most common dosage for the E 404 pill is 30 mg, making it one of the higher-dose IR (instant-release) Adderall tablets available. Compared to E 401 (20 mg) and E 504 (15 mg), the E 404 is identified by its orange color and higher dose.

If you’ve searched what mg is orange Adderall, orange pill with 30, or orange Adderall 30 mg extended release, know that E 404 is typically IR, not XR.

What Is the E 404 Pill Used For?

The E 404 Adderall pill is primarily prescribed for:

• Attention Deficit Hyperactivity Disorder (ADHD)
  
  
• Narcolepsy
  
  

These conditions respond to stimulants that help restore chemical imbalances in the brain. As a result, search terms like orange ADHD pill, orange pill for ADHD, orange pill 404, and round orange pill 20 LCI often relate to Adderall variants like E 404.

How Long Does E 404 Stay in Your System?

As an instant-release (IR) formulation, E 404 typically begins working within 30 minutes, with peak effects in 1–3 hours, and a total duration of about 4–6 hours. However, metabolism, age, and liver function can impact how long it stays detectable.

This section addresses questions like:

• How long does E 404 Adderall last?
  
  
• Is E404 instant release?
  
  
• E 401 orange pill how long does it last?
  
  

E 404 Orange Pill Side Effects

Taking E 404 Adderall can lead to various side effects, both common and severe.

Common side effects may include:

• Dry mouth
  
  
• Insomnia
  
  
• Appetite loss
  
  
• Nervousness
  
  
• Increased heart rate
  
  
• Headaches
  
  

Serious effects to monitor:

• Chest pain or arrhythmias
  
  
• Hallucinations or mood swings
  
  
• High blood pressure
  
  
• Seizures
  
  
• Visual disturbances or confusion
  
  

If any of these occur, especially after mixing Adderall and alcohol or other substances like opioids or cocaine, medical attention is critical.

Drug Interactions and Dangerous Combinations

The E 404 pill can react dangerously with other medications and drugs:

• MAOIs (Monoamine Oxidase Inhibitors): May cause serotonin syndrome
  
  
• Tricyclic antidepressants: Can spike blood pressure
  
  
• Alcohol: Increases risk of vomiting, hallucinations, and overdose
  
  
• Other stimulants: Dangerous synergy with drugs like cocaine
  
  

Many queries, such as 404 e Adderall, orange pill e 401, and adderall capsules orange, are related to users trying to identify safe versus dangerous pills or combinations.

Is the E 404 Orange Pill Addictive?

Yes. As a Schedule II controlled substance, the E 404 Adderall pill is considered high-risk for addiction, especially when taken without a prescription or in high doses.

Those searching for terms like adderall e404, orange pill e404, or little orange round pill may be recreational users or patients unaware of the medication’s addictive properties.

Signs of misuse:

• Taking more than prescribed
  
  
• Combining with alcohol or other drugs
  
  
• Intense cravings or dependency symptoms
  
  

Spotting a Fake E 404 Orange Pill

Counterfeit E 404 pills are a growing problem. Fake versions may contain harmful substances like fentanyl.

To verify a pill’s authenticity:

• Check imprint: E 404
  
  
• Shape: Round, smooth, orange
  
  
• Source: Only obtain from licensed pharmacies
  
  

Keywords like E 404 orange pill fake, pill 44 404, round orange pill A 79 Adderall, or pink Adderall pills often surface in forums discussing counterfeit drugs.

E 404 vs. Other Adderall Variants

Compare the E 404 to other pills in the amphetamine class:

• E 401 pill – Peach/orange, 20 mg
  
  
• E 344 pink pill – Pink, often 30 mg XR
  
  
• N34 orange pill – Another generic amphetamine
  
  
• E 504 / E 505 – Typically 15–20 mg IR
  
  

Often confused pills: orange pill A 08, round orange pill E 34, pill with E, and 401 orange round pill.

When to Seek Help: Adderall Addiction Treatment at Asana Recovery

Misusing pills like E 404, E 401, or A 78 orange pill can lead to long-term physical and mental health problems. If you or someone you know is struggling, Asana Recovery offers personalized, science-backed treatment options.

We specialize in:

• Medical detox
  
  
• Residential inpatient care
  
  
• Dual-diagnosis treatment
  
  
• Group and individual therapy
  
  

Whether you’re worried about Adderall 30 mg pill, orange Xanax, or round orange tablet misuse, we’re here to help.

Start Your Recovery from Adderall Misuse at Asana Recovery

If you or a loved one is misusing Adderall—whether it’s the E 404 orange pill, E 401, or another variant—Asana Recovery is here to help. Our evidence-based treatment programs are designed to address the root causes of stimulant addiction with compassion and clinical precision. From medically supervised detox to ongoing therapy and aftercare, we offer personalized care every step of the way. Don’t wait—reach out today to verify your insurance and begin the path toward lasting recovery.

Frequently Asked Questions (FAQs)

What is the E 404 orange pill used for?

The E 404 orange pill is a generic form of Adderall used to treat ADHD and narcolepsy. It contains a combination of amphetamine and dextroamphetamine, which helps improve focus, reduce impulsivity, and promote wakefulness. Many people searching for terms like “orange ADHD pill” or “round orange pill e 404” are referring to this fast-acting stimulant medication.

Is the E 404 orange pill the same as Adderall?

Yes, the E 404 orange pill is a generic instant-release Adderall tablet, typically containing 30 mg of active stimulant. It delivers the same effects as branded Adderall and is often identified as “adderall round orange pill” or “orange Adderall 30 mg” in online searches.

How long does the E 404 Adderall last in your system?

The E 404 pill is instant release, meaning it usually starts working within 30 minutes and lasts between 4 to 6 hours. This makes it shorter-acting than extended-release versions like those found in “Adderall XR orange and clear capsule”. If you’re wondering “how long does E 404 stay in your system”, it can remain detectable in urine for 2–4 days, depending on metabolism and dosage.

What does the E 404 pill look like and how can I identify it?

The E 404 pill is round, orange, and marked with the imprint “E 404” on one side. It’s commonly confused with other pills like the E 401 orange pill, E 504 pill, or even 44 404 pink pill, so it’s crucial to verify it using a pill identifier tool or by consulting a pharmacist.

Is the E 404 orange pill real or fake? How can I tell?

Due to its popularity and high demand, fake E 404 pills are increasingly common. Authentic pills will be round, smooth, orange, and display the imprint E 404. Counterfeit versions might have faded markings, incorrect color, or unusual effects. Search phrases like “e404 orange pill real or fake” or “fake Adderall E 404” reflect growing concern, especially with the risk of fentanyl-laced fakes. Always obtain medications from a licensed pharmacy.

Can you overdose on the E 404 orange Adderall pill?

Yes. Overdosing on E 404 Adderall can lead to heart palpitations, seizures, hallucinations, and even death. Combining it with other stimulants, alcohol, or depressants increases the risk. Phrases like “E 404 overdose”, “Adderall 404 pill”, and “orange pill 404 dangers” often come up in contexts related to misuse. Always follow your prescribed dosage and consult your doctor.

What’s the difference between E 404 and other Adderall pills like E 401 or E 344?

The E 404 pill usually contains 30 mg of instant-release amphetamine salts. In contrast, E 401 is a 20 mg version, and E 344 is often an extended-release formulation. People often compare “E 404 vs. E 401” or “E 404 vs. E 344 pink pill” when trying to understand which version of Adderall they’ve been prescribed or exposed to.

Is E 404 Adderall addictive?

Yes, E 404 is a Schedule II controlled substance, meaning it has a high potential for abuse and addiction. Individuals who misuse it for performance enhancement or recreational use are at risk. Searches like “adderall e 404 addiction” and “orange round pill dependency” reflect the public’s concern with stimulant misuse. If you or someone you know is struggling, Asana Recovery offers professional, evidence-based support.

Informational Sources 

• National Institute on Drug Abuse. (2021). Prescription stimulants drugfacts. National Institutes of Health. https://nida.nih.gov/publications/drugfacts/prescription-stimulants
• U.S. Food & Drug Administration. (2023). Medication guide: Adderall (amphetamine and dextroamphetamine). https://www.fda.gov/media/78510/download
• Drugs.com. (2024). Amphetamine and dextroamphetamine (Adderall) – Uses, side effects, interactions. https://www.drugs.com/adderall.html
• Substance Abuse and Mental Health Services Administration. (2023). Behavioral health treatment services locator. https://www.samhsa.gov/find-treatment
• MedlinePlus. (2022). Dextroamphetamine and amphetamine. U.S. National Library of Medicine. https://medlineplus.gov/druginfo/meds/a601234.html
• American Addiction Centers. (2024). Adderall addiction: Signs, symptoms, and treatment. https://americanaddictioncenters.org/adderall