Wellbutrin, known generically as bupropion, is a widely prescribed medication for depression, seasonal affective disorder, ADHD (off-label), and smoking cessation. While many patients benefit from its stimulating effects and unique impact on dopamine and norepinephrine, others eventually consider stopping the medication. Whether due to side effects, symptom resolution, or treatment changes, tapering off Wellbutrin requires careful planning. Unlike some medications, Wellbutrin withdrawal doesn’t affect everyone, but when it does, it can be both physically and emotionally taxing.

Understanding how to taper off Wellbutrin, especially dosages like 150 mg or 300 mg of Wellbutrin XL, is essential for minimizing withdrawal symptoms and promoting a smooth transition. Going off Wellbutrin safely means avoiding the cold turkey approach and embracing a gradual, medically guided reduction plan.

Why People Choose to Taper Off Wellbutrin

There are numerous reasons why patients decide to stop taking bupropion. For some, depressive symptoms improve significantly, and long-term medication is no longer necessary. Others experience side effects, such as insomnia, irritability, anxiety, or elevated heart rate (tachycardia), that lead them to consider alternatives. Additionally, switching to another antidepressant or medication class may prompt discontinuation.

Regardless of the reason, it’s important to understand that stopping Wellbutrin suddenly can trigger a range of physical and psychological symptoms. Do you have to taper off Wellbutrin? In most cases, yes—especially for those taking sustained-release (SR) or extended-release (XL) formulations. Gradual tapering prevents destabilization and allows the body time to adjust.

Can You Just Stop Taking Wellbutrin Cold Turkey?

Abruptly stopping Wellbutrin, particularly at higher doses like 300 mg daily, is not recommended. Stopping Wellbutrin cold turkey can lead to withdrawal effects, which may include mood swings, fatigue, dizziness, and flu-like symptoms. These side effects from stopping Wellbutrin are not only uncomfortable but can also mimic a relapse of depression or anxiety, making it difficult to discern what’s happening.

Some people ask, “Can I stop taking Wellbutrin after two weeks?” or “Can I quit Wellbutrin cold turkey?” The answer is: not safely. Bupropion withdrawal symptoms may appear within days and can persist for weeks or even longer if not managed properly.

To reduce the risk of withdrawal symptoms of Wellbutrin, a structured tapering schedule is strongly advised.

Wellbutrin Withdrawal Symptoms and Timeline

Withdrawal from Wellbutrin doesn’t affect everyone the same way. However, those who do experience symptoms often report physical, cognitive, and emotional disruptions that begin 2 to 4 days after stopping the medication. For many, Wellbutrin withdrawal symptoms last one to two weeks, but some users report effects lasting several months.

Common symptoms of Wellbutrin withdrawal include:

• Headaches and dizziness
  
  
• Irritability or mood swings
  
  
• Fatigue and flu-like sensations
  
  
• Anxiety or panic attacks
  
  
• Nausea or digestive discomfort
  
  
• Blurred vision or light sensitivity
  
  
• Difficulty concentrating or memory issues (“brain fog”)
  
  
• Sleep disturbances (insomnia or hypersomnia)
  
  

The intensity and duration of these symptoms depend on several factors, including dosage, how long you’ve been taking Wellbutrin, and whether you’re on the immediate-release, SR, or XL version.

How to Taper Off Wellbutrin Safely

Tapering off Wellbutrin must be done in coordination with a healthcare provider. A personalized tapering schedule will depend on your current dose, medication formulation, and treatment goals.

Wellbutrin Taper Schedule for 150 mg (XL or SR)

If you are taking 150 mg of Wellbutrin XL or SR, a gradual decrease might follow this schedule:

• Weeks 1–2: Reduce to 100 mg daily
  
  
• Weeks 3–4: Reduce to 75 mg daily
  
  
• Weeks 5–6: Discontinue
  
  

This plan helps minimize withdrawal symptoms and gives your body time to adjust to lower doses. Weaning off Wellbutrin slowly is always safer than abrupt cessation, even at lower doses like 150 mg.

Wellbutrin Taper Schedule for 300 mg (XL)

For those on 300 mg XL, your provider may suggest:

• Weeks 1–2: Reduce to 200 mg daily
  
  
• Weeks 3–4: Reduce to 150 mg daily
  
  
• Weeks 5–6: Reduce to 100 mg daily
  
  
• Weeks 7–8: Discontinue
  
  

Decreasing Wellbutrin from 300 to 150 mg too quickly can result in heightened withdrawal symptoms, so it’s crucial to taper in stages.

Tapering Off Lower Doses: 100 mg or 75 mg

Even if you’re on 75 or 100 mg of Wellbutrin, you should still wean off gradually:

• 100 mg → 75 mg → 50 mg → Discontinue
  
  
• 75 mg → 50 mg → Discontinue
  
  

Some patients find it helpful to split tablets or alternate daily doses under medical guidance. Titrating off Wellbutrin slowly can reduce both physical and psychological discomfort.

Coping With Wellbutrin Withdrawal Symptoms

If you’re experiencing Wellbutrin withdrawal, there are several ways to manage your symptoms and improve comfort.

First and foremost, stay in touch with your doctor. Pharmacological support may include sleep aids, anti-anxiety medications, or gastrointestinal remedies to ease specific symptoms. Psychotherapy or support groups can also help with the emotional burden.

You can also:

• Practice relaxation techniques such as mindfulness and deep breathing
  
  
• Stay hydrated and follow a balanced diet
  
  
• Avoid alcohol and recreational substances, which can worsen withdrawal effects
  
  
• Get light exercise, such as walking or yoga, to manage stress and fatigue
  
  

Remember, withdrawal fatigue, headaches, and mood changes are common, but they are usually temporary. If symptoms persist or worsen, adjusting your tapering schedule may be necessary.

Realistic Expectations After Stopping Wellbutrin

Getting off Wellbutrin can bring relief, but it can also reveal underlying conditions that were previously managed by the medication. You might feel tired, foggy, or emotionally off-balance. Some people worry about weight gain, return of depression, or new side effects after stopping bupropion.

That’s why the tapering process should be paired with a long-term plan for mental health support. Whether you’re switching medications, starting therapy, or managing your mental health holistically, recognize that your journey is valid.

Be patient, kind to yourself, and stay committed to communicating with your healthcare provider. Tapering off Wellbutrin doesn’t have to be overwhelming—with the right approach, it can be empowering.

Ready to Take the Next Step Toward Recovery?

If you’re struggling with Wellbutrin withdrawal or thinking about stopping antidepressant medications, you’re not alone. At Asana Recovery, we understand how complex and personal the process of tapering off Wellbutrin—or any medication—can be. Our team of medical and behavioral health professionals is here to provide a safe, compassionate, and structured environment to support you through detox, withdrawal management, and long-term recovery. Whether you’re seeking help for antidepressant discontinuation, substance abuse, or co-occurring disorders, Asana Recovery offers personalized care to help you regain control. Reach out today and begin your path to healing.

FAQs: Wellbutrin Withdrawal, Tapering, and Discontinuation

Do you need to taper off Wellbutrin?

Yes, tapering off Wellbutrin is generally recommended. While some people may tolerate a sudden stop, many experience withdrawal symptoms such as mood swings, dizziness, or headaches if they don’t gradually wean off bupropion. Whether you’re on Wellbutrin XL 150 mg or 300 mg, following a structured taper schedule can help reduce the risk of withdrawal effects and make the process smoother.

What happens if you stop taking Wellbutrin abruptly?

Stopping Wellbutrin cold turkey can lead to a range of withdrawal symptoms, including irritability, fatigue, emotional sensitivity, brain fog, and even flu-like symptoms. These symptoms are part of what’s known as bupropion withdrawal syndrome, and they can begin just a few days after discontinuation. Tapering off Wellbutrin slowly with medical guidance is the safest way to minimize these effects.

How do I taper off Wellbutrin 150 mg safely?

A safe Wellbutrin taper schedule 150 mg often involves reducing the dose in small increments over 6 to 8 weeks. For example:

• Weeks 1–2: Reduce to 100 mg
  
  
• Weeks 3–4: Reduce to 75 mg
  
  
• Weeks 5–6: Reduce to 50 mg
  
  
• Week 7–8: Discontinue
  
  

Always follow a healthcare provider’s advice when adjusting your dose. Tapering off bupropion with professional oversight can prevent unwanted withdrawal symptoms and make the transition easier.

How long does Wellbutrin withdrawal last?

Wellbutrin withdrawal symptoms may begin 2 to 4 days after stopping the medication and typically last between 1 to 2 weeks. However, some individuals report lingering effects for several months, especially after weaning off Wellbutrin after long-term use. A slow taper helps limit the severity and duration of symptoms like anxiety, brain fog, or sleep disturbances.

Is it safe to taper off Wellbutrin XL 300 mg on my own?

No, it’s not recommended to taper off Wellbutrin XL 300 mg without guidance. This higher dose carries a higher risk of withdrawal effects when reduced too quickly. A structured Wellbutrin tapering schedule with a provider may involve stepping down in 75 mg or 100 mg increments every couple of weeks, depending on how your body responds.

Can I take Wellbutrin every other day to taper off?

Taking Wellbutrin every other day is not an ideal method of tapering off. Because Wellbutrin has a specific half-life, this approach can lead to inconsistent blood levels, which may worsen withdrawal symptoms. Instead, a gradual daily dosage reduction — based on a customized bupropion taper schedule — is a safer and more effective strategy.

What are the symptoms of Wellbutrin withdrawal?

Withdrawal from Wellbutrin can cause both physical and emotional symptoms. These may include:

• Mood swings and irritability
  
  
• Headaches and fatigue
  
  
• Dizziness or brain fog
  
  
• Insomnia or vivid dreams
  
  
• Nausea or gastrointestinal upset
  
  

If you’re getting off Wellbutrin, it’s important to track these symptoms and communicate with your healthcare provider to adjust the tapering plan as needed.

Do I have to taper off Wellbutrin even if I’ve only taken it for a few weeks?

Yes, even short-term use can lead to withdrawal symptoms in some people. Stopping Wellbutrin after 1 or 2 weeks might not cause issues for everyone, but others may feel an emotional crash, fatigue, or fogginess. If you’re unsure, consult your doctor about how to taper Wellbutrin safely, even after brief usage.

Can you stop taking bupropion suddenly?

While some individuals tolerate stopping bupropion abruptly, it’s not the safest route for most. Sudden discontinuation — especially from higher doses — can trigger bupropion withdrawal symptoms like agitation, confusion, or anxiety. A gradual tapering plan is the best way to get off bupropion (Wellbutrin) while avoiding rebound effects or emotional distress.

What helps with Wellbutrin withdrawal?

Managing Wellbutrin withdrawal is all about preparation. Here are some tips:

• Follow a personalized Wellbutrin tapering schedule
  
  
• Use mindfulness or cognitive behavioral therapy (CBT) to address mood changes
  
  
• Stay hydrated and get enough sleep
  
  
• Ask your doctor if short-term meds are needed to manage insomnia or anxiety
  
  

Most importantly, don’t stop taking Wellbutrin without guidance — tapering correctly is key to minimizing side effects.

Informational Sources

• Clark, A., Tate, B., Urban, B., Schroeder, R., Gennuso, S., Ahmadzadeh, S., McGregor, D., Girma, B., Shekoohi, S., & Kaye, A. D. (2023). Bupropion mediated effects on depression, attention deficit hyperactivity disorder, and smoking cessation. Health Psychology Research, 11. https://doi.org/10.52965/001c.73631
• Gabriel, M., & Sharma, V. (2017). Antidepressant discontinuation syndrome. CMAJ: Canadian Medical Association Journal, 189(21), E747–E748. https://doi.org/10.1503/cmaj.160902
• Mooney, M. E., & Sofuoglu, M. (2006). Bupropion for the treatment of nicotine withdrawal and craving. Expert Review of Neurotherapeutics, 6(7), 965–981. https://doi.org/10.1586/14737175.6.7.965
• National Institute of Mental Health. (n.d.). Seasonal affective disorder. Retrieved from https://www.nimh.nih.gov/health/publications/seasonal-affective-disorder
• Stall, N., Godwin, J., & Juurlink, D. (2014). Bupropion abuse and overdose. CMAJ: Canadian Medical Association Journal, 186(13), 1015. https://doi.org/10.1503/cmaj.131547
• Statista. (2024, January 4). Number of bupropion prescriptions in the U.S. 2004–2021. Retrieved from https://www.statista.com/statistics/780136/bupropion-prescriptions-number-us/
• Vardanyan, R., & Hruby, V. (2016). Antidepressants. In Synthesis of Best-Seller Drugs (pp. 111–143). Elsevier. https://doi.org/10.1016/B978-0-12-411492-0.00006-5
• Verbeeck, W., Bekkering, G. E., & Kramers, C. (2017). Bupropion for attention deficit hyperactivity disorder (ADHD) in adults. Cochrane Database of Systematic Reviews, 2017(10). https://doi.org/10.1002/14651858.CD011361.pub2