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How Long is Abilify in Your System

How Long is Abilify in Your System

Table of Contents

Abilify (aripiprazole) is a widely prescribed antipsychotic medication that requires careful consideration when starting or stopping treatment. Understanding its metabolism and duration in the body is crucial for safe and effective use.


Metabolism and Processing

Aripiprazole undergoes extensive liver metabolism through two main pathways: CYP2D6 and CYP3A4 enzymes. The drug produces an active metabolite called dehydro-aripiprazole, which represents about 40% of the parent drug’s concentration and maintains similar therapeutic effects.
Key Processing Factors:

  • Well-absorbed with 87% oral bioavailability
  • Peak plasma concentrations occur within 3-5 hours
  • Extensively binds to serum proteins (>99%)
  • Primarily eliminated through hepatic metabolism


Half-Life and Duration

The standard half-life of Abilify varies depending on the formulation and individual factors:
Oral Formulations:

  • Regular metabolizers: 75 hours
  • Poor metabolizers: 146 hours
    Injectable Formulations:
  • Abilify Maintena: 29.9 days (300mg) to 46.5 days (400mg)


    It typically takes about 15 days for oral Abilify to leave your system completely, while injectable forms may take 5-8 months.


Factors Affecting Clearance

Several factors influence how long Abilify remains in your system:
Genetic Factors

  • Poor CYP2D6 metabolizers experience 80% higher aripiprazole exposure
  • CYP2D6 poor metabolizers should receive half the normal dose
    Age and Health
  • Elderly patients show 20% decreased clearance
  • Liver function affects metabolism significantly


Detection and Elimination

The body eliminates Abilify through multiple pathways:

  • 25% excreted in urine
  • 55% eliminated through feces
  • Less than 1% of unchanged aripiprazole appears in urine


Withdrawal Considerations

When discontinuing Abilify, withdrawal symptoms may occur within days of stopping the medication. Common withdrawal effects include:

Physical Symptoms:

  • Lightheadedness
  • Nausea
  • Muscle twitches
  • Sleep disturbances

    Psychological Effects:

  • Anxiety
  • Irritability
  • Worry
  • Dysphoria


Safe Discontinuation

The safest approach to stopping Abilify involves:

  • Gradual dose reduction under medical supervision
  • Monitoring for withdrawal symptoms
  • Regular check-ins with healthcare providers


Struggling with Medication Management? Let Asana Recovery Help

If youā€™re experiencing withdrawal symptoms or need assistance with adjusting your medication, Asana Recovery is here to provide professional support. Our expert team can guide you through safe tapering schedules and personalized treatment plans tailored to your needs. Donā€™t navigate this aloneā€”call us at (949) 763-3440 today and take the first step toward safe and effective medication management.

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